Arachnes are enemies encountered in the DLC Tiny Tina's Assault on Dragon Keep. They are half human, half spider hybrids that wield a bow.
Arachnes are specialized units of spiders. They are larger than most other spiders and wield a bow and arrow. Arachnes primarily attack from a distance using bows that fire arrows in a long arching trajectory. The damage output for each arrow is quite high, although this is offset by a slow rate for fire, and a slow projectile speed that makes them relatively easy to evade at long range. The arrows have a significant impact and any character sprinting towards an Arachne will be momentarily halted when hit by one. If an attacker gets close, Arachnes will resort to using a melee attack that deals corrosive damage. They are vulnerable to incendiary damage and are resistant to corrosive damage. Their abdomen is a critical hit point.
- In Greek mythology, Arachne was a great mortal weaver who boasted her skill was greater than the goddess Athena. After a contest, Athena was enraged by Arachne's skill and turned her into a spider.
- In True Vault Hunter Mode they are renamed Arachne Scourge, and in Ultimate Vault Hunter Mode they are renamed Arachne Reaper.