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Assassin Reeth is an optional boss fought during the side mission Assassinate the Assassins. The Vault Hunters are tasked with killing Reeth, as well as his accomplices Oney, Wot, and Rouf to prevent them from discovering Lilith's whereabouts and selling it to Hyperion.
- Main article: Assassinate the Assassins
- Reeth has a chance to drop his unique Fremington's Edge as well as the legendary Emperor.
- Unlike the usual psychos, Reeth wears no mask and has his head exposed.