Roland: This is a recorded message to any Crimson Raiders in the area. Sanctuary has been targeted by four Hyperion spies masquerading as bandits. They're hiding out in Three Horns -- find 'em, kill 'em, and see if you can figure out why they're here.
(Vault Hunter kills assassin Wot and picks up his ECHO ...)
Handsome Jack: Alright, you mindless gun-hands. You're looking for a really hot chick with blue tattoos and mystical powers. A Siren. Specifically, one named Lilith. The official reports say she died in New Haven, but I'm positive she's hiding out near Sanctuary. If you catch wind of her, tell me and I'll pay you enough money to build a mansion made out of other... smaller mansions. Out.
(Vault Hunter kills assassin Oney and picks up his ECHO ...)
Handsome Jack: Yeah, I just realized, you grunts are gonna get yourselves killed without this little tidbit: all Sirens are born with different, crazy-ass powers. You cannot, I repeat, CANNOT win a fight with them in one on one combat. You see Lilith, contact me IMMEDIATELY. I can handle her -- you can't. Me yes, you no!
(Vault Hunter kills assassin Reeth and picks up his ECHO ...)
Handsome Jack: I found an old recording that might help you guys out with the Siren.
Dr. Patricia Tannis: I've been observing this Siren, Lilith, since the opening of the Vault. She appears to be using Eridium to enhance her natural Phasewalking abilities. This, naturally leads me to assume some unspoken connection between Sirens, Eridium, and the Vault. I have determined two additional things: firstly, that she finds it irritating when others pluck out strands of her hair under the guise of needing them for scientific experimentation, and secondly, that they taste like olives. Wait, no -- fried pickles.
(Vault Hunter kills assassin Rouf and picks up his ECHO ...)
Handsome Jack: "Oh, yeah, and since you shiver-brains evidently don't know how to listen, I'll say it again: stop bringing in fake Sirens. Only six Sirens can exist in the universe at any given time, and I already know of three. You're not gonna convince me you happened to find one of the remaining three just by drawing blue tattoos on some random chick's corpse. I will admit, it was mildly amusing the first dozen times you idiots tried it, but now my office smells like blood and marker fumes. So quit it!
(Vault Hunter returns to Sanctuary and turns in the mission.)