Defender may refer to:
- Defender (class mod, Borderlands) - a class mod available to Lilith in Borderlands.
- Defender (class mod, Borderlands: The Pre-Sequel) - a class mod for Athena in Borderlands: The Pre-Sequel.
- Defender (shotgun) - a legendary Tediore shotgun in Borderlands.
- Defender (assault rifle), an assault rifle manufactured by Dahl in Borderlands 2.