There are three general types of enemies found in Borderlands: creatures, humans, and Guardians, all of whom can come in a Badass (1st Playthrough), BadMutha (2nd Playthrough) version, or SuperBad (After 2nd Playthrough) with the exception of Skags that after 2nd playthrough become "AssKicking".
Several automated weapon systems in Borderlands are also treated as enemies. The Zombie Island of Dr. Ned introduced various creatures of nightmare to the game, loosely collected under the term, "zombie". Claptrap's New Robot Revolution reintroduced the Claptraps as new enemies and added various humans and animals with claptrap robotic upgrades to further swell the Claptrap ranks.
- See also: Claptrap's New Robot Revolution
- See also: Zombie Island of Dr. Ned
- Loot Goon
- Lance Zombie
- Corpse Eater
- Psycho Zombie
- Suicide Zombie
- Main article: Boss
- Main article: Badass