Giant Skeletons are enemies encountered in the DLC Tiny Tina's Assault on Dragon Keep. They are massive, hulking skeletons that wield a bone club as a weapon.
Giant Skeletons are very powerful enemies with a high damage output, but are very slow. They have a very strong ground-pound attack that can easily put a Vault Hunter into Fight For Your Life mode. A Giant Skeleton's critical hit location is its skull, and this will sustain damage up to half the skeleton's health before being blasted away. Despite this, any decapitated Giant Skeleton will continue to fight on until it is completely destroyed. They are resistant to incendiary attacks but vulnerable to corrosive damage.
- In True Vault Hunter Mode they are renamed Hulking Skeleton, and in Ultimate Vault Hunter Mode they are renamed Towering Skeleton.
- Destroying a Giant Skeleton contributes to the Bone Breaker challenge in the challenge list.