The Handsome Dragon first appears at the Unassuming Docks, when it appears as the first boss. When first encountered, it cannot be damaged. The Dragon then spews a fireball that can easily down a character, before it is removed from the game to be replaced with a different boss known as Mister Boney Pants Guy.
- In its first appearance the Handsome Dragon is mistakenly added to Tiny Tina's game by Tina herself before Lilith argues against putting such a powerful boss in the start of the game.
- The Handsome Dragon commonly drops Eridium, several blue and purple rarity items (including spell grenades), numerous stacks of money and a chance to drop the legendary submachine-gun Slagga.
- The Handsome Sorcerer refers to the Handsome Dragon as Smokey.
- The Handsome Dragon is Tina's allegory for The Warrior.