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Heart of the Ancients is an E-tech relic manufactured by the Eridians. Heart of the Ancients is obtained randomly from any suitable loot source and has an increased drop from Legendary Loot Midgets in Ultimate Vault Hunter Mode.
Heart of the Ancients will always have traits from both an Aggression Relic (increased damage from any single weapon type) and a Tenacity Relic (increased Fight for Your Life time and/or increased Second Wind Health)
Heart of the Ancients, like Tenacity Relic, can allow the user to have health gate immediately upon getting a Second Wind. This can potentially replace the need for healing weapons.