Karima was once a computer technician before her husband, the previous administrator of Overlook, was pushed into the town grinder by agents of Hyperion. The burden of leadership then fell to Karima, who painfully tries to keep the town going while enduring her disorder and enduring a running commentary from the local misogynist, Dave.
Karima is the administrator of Overlook, and tries to help her small town by offering three missions to the Vault Hunters who drove back a Hyperion attack in the community. These missions involve obtaining medication to combat the effects of the skull-shivers and then building a defensive shield to keep the townsfolk safe from Hyperion attack.
The Vault Hunters also interact briefly with Karima while experiencing Claptrap's memories in the Claptastic Voyage DLC from Borderlands: The Pre-Sequel. She is met in person and asks Claptrap to take a collection of first aid equipment to her husband, Danny.
- Due to suffering from skull-shivers, she speaks with a stutter and sometimes has problems saying certain words, until she takes the medicine during mission The Overlooked: Medicine Man.
- Despite the fact that her house isn't one of the places the Vault Hunters deliver medicine to during The Overlooked: Medicine Man, she still appears to be cured at the end of the mission.
- In Borderlands: The Pre-Sequel's DLC Claptastic Voyage, Karima appears briefly during the mission The Psychology of a Claptrap. She is seen as a live person, although it should be noted that this is a visual representation of Claptrap's memories of her. This Karima also speaks with a stutter.