The road to New Haven goes through an arena which Mad Mel controls. Mad Mel must be defeated for the story to proceed any further.
- Main article: Road Warriors: Bandit Apocalypse
"Yeah! Hahaha! Better run!" (Just before Mad Mel appears in the arena)
- Mad Mel's name is an amalgamation of the title of a popular post-apocalyptic movie, Mad Max; and the actor who portrayed the titular character of Max, Mel Gibson. The text describing the mission to kill Mad Mel also refers to him as a "lethal weapon behind the wheel of any vehicle;" Mel Gibson starred in the Lethal Weapon series of action films.
- When Helena Pierce offers a reward for killing Mad Mel, she says, "It's great to see someone with a brave heart willing to go out there and live dangerously." Mel Gibson played the leading role in the movie Braveheart, and opposite Sigourney Weaver in "The Year of Living Dangerously".
- Mad Mel strongly resembles Lord Humungous, the main antagonist of Mad Max 2. The Monster he drives also resembles the character's six-wheeled truck in the film.
- Mad Mel uses the character model of a badass bruiser.
- Mad Mel will not respawn after Playthrough 2, unlike most bosses.