Whilst basic anti-skag strategy can be applied to this pair, often additional measures need to be taken by less experienced players who find this fight a challenging one. Players using Mordecai have been especially noted for having their work cut out for them here, as this character often has a limited effectiveness at close ranges. Jumping up onto the sides of Nine-Toes' arena can place a character out of harm's way. The skags are able to make the same ascent, however they frequently land on the bleachers which can still keep them at a distance.
Both Pinky and Digit are known to display charging attacks usually exhibited by higher level skags. They have been known to roar immediately as they appear. If equipped with an accurate weapon, it is possible to achieve at least one critical shot when they appear, making the fight considerably easier.
They both have heavily armoured backs, giving them having a high bullet resistance (possibly greater than that of Alpha Skags), making them difficult to take down.
Killing Nine-Toes first and picking up The Clipper can make this fight all the more easier, as the gun's fire element is quite effective against flesh.
Their names are both references to toes, continuing the theme of Nine-Toes' name and the name of the gun he drops, The Clipper.
While their Master does respawn during playthroughs, these skags only spawn once per playthrough, a rarity for most of the game's boss-type enemies.