Psycho Zombies bear many characteristics of the normal Psycho, save the obvious. They can use the standard Zombie's puking attack and enter a berserk state with enhanced movement speed upon taking damage from a Vault Hunter. After flinching from the initial shot, its eyes will glow blood red and movement speed will be dramatically increased.
The best way to deal with a Psycho Zombie is to stay out of its range and aim for the head with a high damage sniper rifle or high-accuracy shotgun if it gets too close. Compared to other Zombies, its melee attack is much faster and more lethal. They also have a habit of zig zagging while up close while being avoided, making close range combat incredibly dangerous even for a zombie.
Psycho Zombies can be observed, using a Sniper Rifle or other weapon with a large zoom, moving at extreme speed from a distance. When they are shot, they will return to their normal speed until they take enough damage to activate "Rage Mode."