Skeleton Seers are tricky and deadly enemies, capable of dealing large amounts of shock damage before vanishing in a puff of smoke. Skeleton Seers shoot balls of electricity from their hands which can swiftly deplete shields. With no apparent pattern, they will disappear for a short while and reappearing elsewhere, occasionally behind a Vault Hunter. A small blue orb follows the Seer while invisible which can help indicate where it will reappear. If applied with Death Mark before vanishing, their position will also be tracked by the red 0. Unlike other enemies with the ability to cloak themselves, while invisible Seers remain so to Zer0 during Decepti0n.
Skeleton Seer's skulls are critical hit points, although their helmets must be shot off first before the skull can be hit. Their skulls can withstand hits until their health is reduced to half, then their skull is destroyed. Destroying their skull does not necessarily kill a Skeleton Seer, they will fight on headless until killed. Skeleton Seers are resistant to incendiary damage but are vulnerable to corrosive damage.
Throwing a couple of singularity grenades with extremely short fuse the moment they appear will have them snared in the gravitational pull, unable to vanish and giving Vault Hunters several seconds to keep them in sight.
- In True Vault Hunter Mode, Skeleton Seers are renamed "Skeleton Conjurers."
- In Ultimate Vault Hunter Mode, Skeleton Seers are renamed "Skeleton Mages".
- While invisible, status effects applied to a Seer will cease, and they will not be influenced by the effects of singularity grenades.